Gerard Madlambayan

Gerard Madlambayan
Professor, Ph.D.
Office: 325 & 376 DH
(248) 370-3585
(248) 370-3580
Lab: 324 & 326 DH
(248) 370-3663
[email protected]

Courses:

BIO 1200 Biology I
BE 4300 Bioprocess Engineering

Research: The Role of Stem Cells in Cancer

Many cancers initiate from specific cancer stem/initiating cells (CSCs). While the field of CSCs is under considerable investigation, Dr. Madlambayan’s research utilizes a more global approach to define the integrated roles of different stem and progenitor cell populations in cancer initiation, progression and relapse. Dr. Madlambayan’s work has shown that bone marrow-derived stem cells including blood stem cells play a role in the growth of some cancers (lung and pancreatic) but not others (melanoma). He has also found that endothelial progenitor cells play an important role in the progression of blood related cancers. Dr. Madlambayan is also involved in discovering why regenerative microenvironments (i.e. limbs and tails) resist cancer growth using a salamander/axolotl animal model (Ambystoma Mexicanum). The overall goal of his research is to apply these findings towards developing clinically relevant drugs and drug delivery strategies to treat these diseases.

Selected Publications:

Gerard Madlambayan NCBI publication list

Li, X., Y. Su, G. Madlambayan, H. Edwards, L. Polin, J. Kushner, S.H. Dzinic, K. White, J. Ma, T. Knight, G. Wang, Y. Wang, J. Yang, J.W. Taub, H. Lin and Y. Ge. (2020). Antileukemic activity and mechanism of action of the novel PI3K and histone deacetylase dual inhibitor CUDC-907 in acute myeloid leukemia. Haematologica 105: Epub ahead of print. DOI: 10.3324/haematol.2018.201343.

Li,X. Y. Su, K. Hege*, G. Madlambayan, H. Edwards, T. Knight, L. Polin, J. Kushner, S.H. Dzinic, Kl White, J, Yang, R. Miller*, G. Wang, L. Zhao, Y. Wang, H. Lin, J. W. Taub and Y. Ge. (2020). The HDAC and PI3K dual inhibitor CUDC-907 synergistically enhances the antileukemic activity of venetoclax in preclinical models of acute myeloid leukemia. Haematologica epub ahead of print. DOI: 10.3324/haematol.2019.233445. 

Vijay, V., R. Miller*, G.S. Vue*, M.B. Pezeshkian*, M. Maywood, A.M Ast, L.M. Drusbosky, Y. Pompeu, A.D. Salgado, S.D. Lipten, T. Geddes, A.M Blenc, Y. Ge, D.A Ostrov, C.R. Cogle and G. J. Madlambayan. (2019). Interleukin-8 blockade prevents activated endothelial cell mediated proliferation and chemoresistance of acute myeloid leukemia. Leukemia Research 84:106180. DOI: 10.1016/j.leukres.2019.106180.

Bigoni-Ordóñez, G.D., D. Czarnowski*, T. Parsons*, G.J. Madlambayan and L.G. Villa-Diaz. (2018). Integrin α6 (CD49f), the microenvironment and cancer stem cells. Current Stem Cell Research & Therapy 14(5): 428-436. DOI: 10.2174/1574888X13666181002151330.

Kane*, J.L., S.A. Krueger, A. Hanna, T.R. Raffel, G.D. Wilson, G.J. Madlambayan and B. Marples. (2016). Effect of irradiation on tumor microenvironment and bone marrow cell migration in a preclinical tumor model. International Journal of Radiation Oncology Biology Physics 96: 170-178. DOI: 10.1016/j.ijrobp.2016.04.028.

Qi, W., W. Zhang, H. Edwards, R. Chu, G.J. Madlambayan, J.W. Taub, Z. Wang, Y. Wang, C. Li, H. Lin and Y. Ge. (2015). Synergistic anti-leukemic interactions between panobinostat and MK-1775 in acute myeloid leukemia ex vivo. Cancel Biology & Therapy 16: 1784-1793. DOI: 10.1080/15384047.2015.1095406.

Tan, L., P. Lin, B. Pezeshkian*, A. Rehman, G. Madlambayan, and X. Zeng. (2014). Real-time monitoring of cell mechanical changes induced by endothelial cell activation and their subsequent binding with leukemic cell lines. Biosensors & Bioelectronics 56: 151-158. DOI: 10.1016/j.bios.2014.01.004 

Pezeshkian*, B., C. Donnelly, K. Tamburo, T. Geddes, and G.J. Madlambayan. (2013). Leukemia mediated endothelial cell activation modulated leukemia cell susceptibility to chemotherapy through a positive feedback loop mechanism. PLoS One 8: e60823. DOI: 10.1371/journal.pone.0060823. 

*OU student