Sang Rhee

Sang Hoon Rhee
Associate Professor, Ph.D.
330 DH
248-370-4162
Lab Location: 331 & 332 DH
Lab Phone: (248) 370-3589
FAX (248) 370-4225
[email protected]

Courses:

BIO 4226 Immunology
BIO 5226 Immunology
BIO 5610 Advance Topics Cell Physiology

Research: Mucosal Immunology and Gut Epithelial Biology

The gut-brain interaction associated with mucosal immunology in the gastrointestinal tract. Molecular and cellular mechanism of gut epithelial cell physiology. Development of preventive and therapeutic approaches to gut inflammatory disorders, such as inflammatory bowel diseases, in humans.

Selected Publications:

Sang Hoon Rhee NCBI My Bibliography

Mitchell* J, S.J. Kim*, C. Howe*, S. Lee, Y.J. Her, M. Patel*, G. Kim*, J. Lee, E. Im, and S.H. Rhee. (2022) Chronic intestinal inflammation suppresses brain activity by inducing neuroinflammation in mice. The American Journal of Pathology 192:72-86. DOI: 10.1016/j.ajpath.2021.09.006.

Kim* S.J., C. Howe*, J Mitchell*, J. Choo, A. Powers*, A. Oikonomopoulos, C. Pothoulakis, D.W. Hommes, E. Im, and S.H. Rhee (2020). Autotaxin loss accelerates intestinal inflammation by suppressing TLR4-mediated immune responses. EMBO Reports 21: e49332. PubMed PMID: 32875703; DOI: 10.15252/embr.201949332.

Howe*, C., J. Mitchell*, S.J. Kim, E. Im and S.H. Rhee. (2019). Pten gene deletion in intestinal epithelial cells enhances susceptibility to Salmonella Typhimurium infection in mice. Journal of Microbiology 57: 1012–1018. DOI: 10.1007/s12275-019-9320-3.

Mitchell*, J., S.J. Kim, A. Seelmann, B. Veit*, B. Shepard*, E. Im, and S.H. Rhee. (2018). Src family kinase tyrosine phosphorylates Toll-like receptor 4 to dissociate MyD88 and Mal/Tirap, suppressing LPS-induced inflammatory responses. Biochemical Pharmacology 147:119-127. DOI: 10.1016/j.bcp.2017.11.015.

Mitchell*, J., S.J. Kim*, G. Koukos, A. Seelmann, B. Veit*, B. Shepard*, S. Blumer-Schuette, H.S. Winter, D. Iliopoulos, C. Pothoulakis, E. Im and S.H. Rhee. (2018). Colonic inhibition of phosphatase and tensin homolog (Pten) increases colitogenic bacteria, causing the development of colitis in Il10-/- mice. Inflammatory Bowel Diseases 24:1718-1732. DOI:10.1093/ibd/izy124.

Howe*, C., S.J. Kim*, J. Mitchell*, E. Im, Y.S. Kim, Y.S. Kim and S.H. Rhee. (2018) Differential expression of tumor-associated genes and altered gut microbiome with decreased Akkermansia muciniphila confer a tumor-preventive microenvironment in intestinal epithelial Pten deficient mice. Biochimica et Biophysica Acta- Molecular Basis of Disease 1864: 3746-3758. DOI: 10.1016/j.bbadis.2018.10.006.

*Oakland University student